Dopamine 2 and Somatostatin 1-5 Receptors Coexpression in Clinically Non-Functioning Pituitary Adenomas

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10296074" target="_blank" >RIV/00216208:11110/15:10296074 - isvavai.cz</a>

Alternative codes found

RIV/61383082:_____/15:#0000380 RIV/00216208:11150/15:10296074 RIV/00179906:_____/15:10296074 RIV/00064165:_____/15:10296074

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/64/64_369.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/64/64_369.pdf</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Dopamine 2 and Somatostatin 1-5 Receptors Coexpression in Clinically Non-Functioning Pituitary Adenomas

Original language description

This study investigated quantitated expression of dopamine 2 receptor (D2R) and somatostatin receptors of the five types (SSTR1-SSTR5) in a large series of clinically non-functioning pituitary adenomas (CNFAs). Co-expression of these receptors in individual adenomas was studied as well as correlation between receptor types. Adenoma tissue from 198 patients who underwent surgery for CNFAs was analyzed by immunohistochemistry and quantitative real-time PCR. D2R and SSTR1-3 mRNA was expressed in all 198 adenomas. SSTR4 and SSTR5 were detectable in 85 % and 61 % of adenomas, respectively. Expression of D2R was significantly higher than that of the somatostatin receptors. The median relative expressions were as follows from highest D2R >> SSTR3 > SSTR2 > SSTR1 > SSTR5 > SSTR4. High relative expression (ratio to beta-glucuronidase mRNA > 1) of D2R was found in 60 % of tumors, high expression of SSTR1 in 7.5 %, SSTR2 in 7 %, SSTR3 in 4 % and SSTR5 in 0.5 %. The quantity of D2R correlated posi

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

—

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

—

Volume of the periodical

64

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

369-377

UT code for WoS article

000357411100009

EID of the result in the Scopus database

2-s2.0-84934273195