Magnetic Resonance Phase Alterations in Multiple Sclerosis Patients with Short and Long Disease Duration
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10296092" target="_blank" >RIV/00216208:11110/15:10296092 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/15:10296092
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0128386" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0128386</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0128386" target="_blank" >10.1371/journal.pone.0128386</a>
Alternative languages
Result language
angličtina
Original language name
Magnetic Resonance Phase Alterations in Multiple Sclerosis Patients with Short and Long Disease Duration
Original language description
Objective The analysis of the MR phase provides additional information on the tissue microstructure. In multiple sclerosis (MS) lesions phase alterations may reflect different stages of inflammatory activity. Here we investigated lesion morphology in MSpatients with short and long disease duration on T2* weighted, phase, magnitude and susceptibility weighted imaging (SWI) at 7 Tesla (T). Methods 17 MS or clinically isolated syndrome patients with short (<60 months) and 11 with long (>60 months) diseaseduration underwent 7T MRI. Lesions were subsequently analyzed side-by-side with regard to morphology and visibility on T2* weighted, SWI, magnitude and SWI-filtered phase images. Results 126 of 192 T2* weighted lesions (65.6%) were characterized by a phase alteration pattern, and hence could be differentiated on phase images. In detail, a significantly reduced proportion of lesions showing phase alterations was detectable in patients with longer disease duration (mean +/- SD 51 +/- 37%,
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
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UT code for WoS article
000358198700003
EID of the result in the Scopus database
2-s2.0-84940185620