Atypical Polypoid Adenomyoma of the Uterus An Immunohistochemical and Molecular Study of 21 Cases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10296269" target="_blank" >RIV/00216208:11110/15:10296269 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/15:10296269 RIV/00216208:11150/15:10296269 RIV/00179906:_____/15:10296269 RIV/00064203:_____/15:10296269 RIV/00064165:_____/15:10296269
Result on the web
<a href="http://dx.doi.org/10.1097/PAS.0000000000000428" target="_blank" >http://dx.doi.org/10.1097/PAS.0000000000000428</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/PAS.0000000000000428" target="_blank" >10.1097/PAS.0000000000000428</a>

Result language
angličtina
Original language name
Atypical Polypoid Adenomyoma of the Uterus An Immunohistochemical and Molecular Study of 21 Cases
Original language description
Atypical polypoid adenomyoma (APA) is an uncommon uterine lesion that commonly recurs after local excision and is occasionally associated with or precedes the development of atypical hyperplasia or endometrioid adenocarcinoma. Despite the fact that about230 cases have been reported in the literature, only 2 studies of 6 and of 7 cases have investigated the molecular aspects; as such, molecular alterations that occur in APA remain largely unknown. We undertook a comprehensive immunohistochemical and molecular analysis of 21 cases of APA in 17 patients (including 4 recurrent/persistent lesions). The analyzed genes were PTEN and TP53 (by fluorescence in situ hybridization) and KRAS, BRAF, EGFR, and NRAS (all by polymerase chain reaction). Immunohistochemical staining was performed for PTEN, p53, mTOR, -catenin, HNF-1, and GLUT1 and for the mismatch-repair proteins MLH-1, MSH-2, MSH-6, and PMS-2. In most cases, there was nuclear expression of -catenin in squamous morules and expression of
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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