IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10296775" target="_blank" >RIV/00216208:11110/15:10296775 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/15:10296775 RIV/00216208:11160/15:10296775
Result on the web
<a href="http://ajprenal.physiology.org/content/308/5/F388.full" target="_blank" >http://ajprenal.physiology.org/content/308/5/F388.full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1152/ajprenal.00266.2014" target="_blank" >10.1152/ajprenal.00266.2014</a>

Result language
angličtina
Original language name
IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats
Original language description
The aim of our study was to investigate whether two potent anti-inflammatory agents, dexamethasone and anakinra, an IL-1 receptor antagonist, may influence acute kidney injury (AKI) and associated drug excretory functions during endotoxemia (LPS) in rats. Ten hours after LPS administration, untreated endotoxemic rats developed typical symptoms of AKI, with reduced GFR, impaired tubular excretion of urea and sodium, and decreased urinary excretion of azithromycin, an anionic substrate for multidrug resistance-transporting proteins. Administration of both immunosuppressants attenuated the inflammatory response, liver damage, AKI, and increased renal clearance of azithromycin mainly by restoration of GFR, without significant influence on its tubular secretion. The lack of such an effect was related to the differential effect of both agents on the renal expression of individual drug transporters. Only dexamethasone increased the urinary clearance of bile acids, in accordance with the reduc
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/EE2.3.30.0061" target="_blank" >EE2.3.30.0061: Increasing of the R&D capacity at Charles University through new positions for graduates of doctoral studies</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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