Increasing venoarterial extracorporeal membrane oxygenation flow negatively affects left ventricular performance in a porcine model of cardiogenic shock

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10297280" target="_blank" >RIV/00216208:11110/15:10297280 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21460/15:00237901

Result on the web

<a href="http://dx.doi.org/10.1186/s12967-015-0634-6" target="_blank" >http://dx.doi.org/10.1186/s12967-015-0634-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12967-015-0634-6" target="_blank" >10.1186/s12967-015-0634-6</a>

Result language

angličtina

Original language name

Increasing venoarterial extracorporeal membrane oxygenation flow negatively affects left ventricular performance in a porcine model of cardiogenic shock

Original language description

Background: The aim of this study was to assess the relationship between extracorporeal blood flow (EBF) and left ventricular (LV) performance during venoarterial extracorporeal membrane oxygenation (VA ECMO) therapy. Methods: Five swine (body weight 45kg) underwent VA ECMO implantation under general anesthesia and artificial ventilation. Subsequently, acute cardiogenic shock with signs of tissue hypoxia was induced. Hemodynamic and cardiac performance parameters were then measured at different levelsof EBF (ranging from 1 to 5 L/min) using arterial and venous catheters, a pulmonary artery catheter and a pressure-volume loop catheter introduced into the left ventricle. Results: Myocardial hypoxia resulted in a decline in mean (+/- SEM) cardiac outputto 2.8 +/- 0.3 L/min and systolic blood pressure (SBP) to 60 +/- 7 mmHg. With an increase in EBF from 1 to 5 L/min, SBP increased to 97 +/- 8 mmHg (P < 0.001); however, increasing EBF from 1 to 5 L/min significantly negatively influences

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Translational Medicine

ISSN

1479-5876

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

August

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

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UT code for WoS article

000359451700001

EID of the result in the Scopus database

2-s2.0-84939148757