Cannabinoid-Induced Changes in the Activity of Electron Transport Chain Complexes of Brain Mitochondria

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10297789" target="_blank" >RIV/00216208:11110/15:10297789 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s12031-015-0545-2" target="_blank" >http://dx.doi.org/10.1007/s12031-015-0545-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12031-015-0545-2" target="_blank" >10.1007/s12031-015-0545-2</a>

Result language

angličtina

Original language name

Cannabinoid-Induced Changes in the Activity of Electron Transport Chain Complexes of Brain Mitochondria

Original language description

The aim of this study was to investigate changes in the activity of individual mitochondrial respiratory chain complexes (I, II/III, IV) and citrate synthase induced by pharmacologically different cannabinoids. In vitro effects of selected cannabinoids on mitochondrial enzymes were measured in crude mitochondrial fraction isolated from pig brain. Both cannabinoid receptor agonists, Delta(9)-tetrahydrocannabinol, anandamide, and R-(+)-WIN55,212-2, and antagonist/inverse agonists of cannabinoid receptors,AM251, and cannabidiol were examined in pig brain mitochondria. Different effects of these cannabinoids on mitochondrial respiratory chain complexes and citrate synthase were found. Citrate synthase activity was decreased only by Delta(9)-tetrahydrocannabinol and AM251. Significant increase in the complex I activity was induced by anandamide. At micromolar concentration, all the tested cannabinoids inhibited the activity of electron transport chain complexes II/III and IV. Stimulatory e

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Molecular Neuroscience

ISSN

0895-8696

e-ISSN

—

Volume of the periodical

56

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

926-931

UT code for WoS article

000360073100021

EID of the result in the Scopus database

2-s2.0-84938998302