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Mitochondrial ATP synthasome: Expression and structural interaction of its components

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10297791" target="_blank" >RIV/00216208:11110/15:10297791 - isvavai.cz</a>

  • Alternative codes found

    RIV/67985823:_____/15:00448195

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.bbrc.2015.07.034" target="_blank" >http://dx.doi.org/10.1016/j.bbrc.2015.07.034</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.bbrc.2015.07.034" target="_blank" >10.1016/j.bbrc.2015.07.034</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Mitochondrial ATP synthasome: Expression and structural interaction of its components

  • Original language description

    Mitochondrial ATP synthase, ADP/ATP translocase (ANT), and inorganic phosphate carrier (PiC) are supposed to form a supercomplex called ATP synthasome. Our protein and transcript analysis of rat tissues indicates that the expression of ANT and PiC is transcriptionally controlled in accordance with the biogenesis of ATP synthase. In contrast, the content of ANT and PiC is increased in ATP synthase deficient patients' fibroblasts, likely due to a post-transcriptional adaptive mechanism. A structural analysis of rat heart mitochondria by immunoprecipitation, blue native/SDS electrophoresis, immunodetection and MS analysis revealed the presence of ATP synthasome. However, the majority of PiC and especially ANT did not associate with ATP synthase, suggesting that most of PiC, ANT and ATP synthase exist as separate entities. (C) 2015 Published by Elsevier Inc.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biochemical and Biophysical Research Communications

  • ISSN

    0006-291X

  • e-ISSN

  • Volume of the periodical

    464

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    787-793

  • UT code for WoS article

    000359881900018

  • EID of the result in the Scopus database

    2-s2.0-84938745041