Effect of cancer-associated fibroblasts on the migration of glioma cells in vitro
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10297878" target="_blank" >RIV/00216208:11110/15:10297878 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s13277-015-3259-8" target="_blank" >http://dx.doi.org/10.1007/s13277-015-3259-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13277-015-3259-8" target="_blank" >10.1007/s13277-015-3259-8</a>
Alternative languages
Result language
angličtina
Original language name
Effect of cancer-associated fibroblasts on the migration of glioma cells in vitro
Original language description
Cancer-associated fibroblasts (CAFs) significantly influence biological properties of many tumors. The role of these mesenchymal cells is also anticipated in human gliomas. To evaluate the putative role of CAFs in glioblastoma, we tested the effect of CAF conditioned media on the proliferation and chemotaxis of glioma cells. The proliferation of glioma cells was stimulated to similar extent by both the normal fibroblasts (NFs) and CAF-conditioned media. Nevertheless, CAF-conditioned media enhanced the chemotactic migration of glioma cells significantly more potently than the media from normal fibroblasts. In order to determine whether CAF-like cells are present in human glioblastomas, immunofluorescence staining was performed on tissue samples from 20patients using markers typical for CAFs. This analysis revealed regular presence of mesenchymal cells expressing characteristic CAF markers alpha-smooth muscle actin and TE-7 in human glioblastomas. These observations indicate the potenti
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Tumor Biology
ISSN
1010-4283
e-ISSN
—
Volume of the periodical
36
Issue of the periodical within the volume
8
Country of publishing house
CH - SWITZERLAND
Number of pages
7
Pages from-to
5873-5879
UT code for WoS article
000360193800021
EID of the result in the Scopus database
2-s2.0-84940435092