Recent-onset dilated cardiomyopathy associated with Borrelia burgdorferi infection

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10297942" target="_blank" >RIV/00216208:11110/15:10297942 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/15:00063106 RIV/75010330:_____/15:00010985 RIV/00064165:_____/15:10297942
Result on the web
<a href="http://dx.doi.org/10.1007/s00059-015-4308-1" target="_blank" >http://dx.doi.org/10.1007/s00059-015-4308-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00059-015-4308-1" target="_blank" >10.1007/s00059-015-4308-1</a>

Result language
angličtina
Original language name
Recent-onset dilated cardiomyopathy associated with Borrelia burgdorferi infection
Original language description
Several recent small studies have suggested a causal link between Lyme disease and dilated cardiomyopathy (DCM) by demonstrating the presence of the Borrelia burgdorferi (Bb) genome in the myocardium of patients with recent-onset DCM. The aim of this study was to further investigate the effect of targeted antibiotic treatment of Bb-related recent-onset DCM in a larger cohort of patients. We performed endomyocardial biopsy (EMB) in 110 individuals (53 +/- 11 years, 34 women) with recent-onset unexplainedDCM, and detected the Bb genome in 22 (20 %) subjects. Bb-positive patients were subsequently treated with intravenous ceftriaxone for 21 days in addition to conventional heart failure medication. At the 1-year follow-up, a significant improvement in left ventricular (LV) ejection fraction (26 +/- 6 vs. 44 +/- 12 %; p < 0.01) and a decrease in LV end-diastolic (69 +/- 7 vs. 63 +/- 11 mm; p < 0.01) and end-systolic (61 +/- 9 vs. 52 +/- 4 mm; p < 0.01) diameters were documented. Moreover,
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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