Searching therapeutic agents for treatment of Alzheimer disease using the Monte Carlo method
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10297943" target="_blank" >RIV/00216208:11110/15:10297943 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/15:10297943
Result on the web
<a href="http://dx.doi.org/10.1016/j.compbiomed.2015.06.019" target="_blank" >http://dx.doi.org/10.1016/j.compbiomed.2015.06.019</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.compbiomed.2015.06.019" target="_blank" >10.1016/j.compbiomed.2015.06.019</a>
Alternative languages
Result language
angličtina
Original language name
Searching therapeutic agents for treatment of Alzheimer disease using the Monte Carlo method
Original language description
Quantitative structure - activity relationships (QSARs) for the pIC50 (binding affinity) of gammasecretase inhibitors can be constructed with the Monte Carlo method using CORAL software (http://www.insilico.eu/coral). The considerable influence of the presence of rings of various types with respect to the above endpoint has been detected. The mechanistic interpretation and the domain of applicability of the QSARs are discussed. Methods to select new potential gamma-secretase inhibitors are suggested.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Computers in Biology and Medicine
ISSN
0010-4825
e-ISSN
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Volume of the periodical
64
Issue of the periodical within the volume
September
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
148-154
UT code for WoS article
000361412500014
EID of the result in the Scopus database
2-s2.0-84936854839