Lenalidomide treatment induced the normalization of marker protein levels in blood plasma of patients with 5q-myelodysplastic syndrome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10306870" target="_blank" >RIV/00216208:11110/15:10306870 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/15:10306870

Result on the web

<a href="https://www.researchgate.net/profile/Albert_Breier2/publication/277079726_Lenalidomide_treatment_induced_the_normalization_of_marker_protein_levels_in_blood_plasma_of_patients_with_5q-myelodysplastic_syndrome/links/5606528208aeb5718ff29392.pdf" target="_blank" >https://www.researchgate.net/profile/Albert_Breier2/publication/277079726_Lenalidomide_treatment_induced_the_normalization_of_marker_protein_levels_in_blood_plasma_of_patients_with_5q-myelodysplastic_syndrome/links/5606528208aeb5718ff29392.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Lenalidomide treatment induced the normalization of marker protein levels in blood plasma of patients with 5q-myelodysplastic syndrome

Original language description

A specific type of myelodysplastic syndrome (MDS) is associated with isolated deletion on the long arm of chromosome 5, i.e., 5q-syndrome (del(5q)). The treatment approaches for MDS del(5q) include the immunomodulating drug lenalidomide (LEN). Thirteen MDS del(5q) patients were included in this study. We found elevated activities of lactate dehydrogenase (LDH) and matrix metalloproteinase 9 (MMP-9) in the blood plasma of MDS del(5q) patients as compared with healthy controls. This was stabilized to control values after LEN treatment. Similar behavior we registered also for the thioredoxin and calnexin contents in BP. Peripheral blood mononuclear cells (PBMC) from patients with MDS del(5q) prior to and after treatment with LEN did not exhibit any detectable amount of P-glycoprotein (P-gp) gene transcript. However, we detected a measurable amount of multidrug resistance associated protein 1 (MRP1) mRNA in PBMCs from three patients prior to LEN treatment and in one patient during LEN trea

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

General Physiology and Biophysics

ISSN

0231-5882

e-ISSN

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Volume of the periodical

34

Issue of the periodical within the volume

4

Country of publishing house

SK - SLOVAKIA

Number of pages

8

Pages from-to

399-406

UT code for WoS article

000362149900005

EID of the result in the Scopus database

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