Cancer Microenvironment: What Can We Learn from the Stem Cell Niche
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10312147" target="_blank" >RIV/00216208:11110/15:10312147 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/15:10312147 RIV/00064203:_____/15:10312147
Result on the web
<a href="http://www.mdpi.com/1422-0067/16/10/24094" target="_blank" >http://www.mdpi.com/1422-0067/16/10/24094</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms161024094" target="_blank" >10.3390/ijms161024094</a>
Alternative languages
Result language
angličtina
Original language name
Cancer Microenvironment: What Can We Learn from the Stem Cell Niche
Original language description
Epidermal stem cells (ESCs) are crucial for maintenance and self- renewal of skin epithelium and also for regular hair cycling. Their role in wound healing is also indispensable. ESCs reside in a defined outer root sheath portion of hair follicle-also known as the bulge region. ECS are also found between basal cells of the interfollicular epidermis or mucous membranes. The non-epithelial elements such as mesenchymal stem cell-like elements of dermis or surrounding adipose tissue can also contribute to this niche formation. Cancer stem cells (CSCs) participate in formation of common epithelial malignant diseases such as basal cell or squamous cell carcinoma. In this review article, we focus on the role of cancer microenvironment with emphasis on the effect of cancer-associated fibroblasts (CAFs). This model reflects various biological aspects of interaction between cancer cell and CAFs with multiple parallels to interaction of normal epidermal stem cells and their niche. The complexity
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
10
Country of publishing house
CH - SWITZERLAND
Number of pages
17
Pages from-to
24094-24110
UT code for WoS article
000364232100052
EID of the result in the Scopus database
2-s2.0-84944028806