Resting-state functional magnetic resonance imaging of the subthalamic microlesion and stimulation effects in Parkinson's disease : Indications of a principal role of the brainstem

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10312356" target="_blank" >RIV/00216208:11110/15:10312356 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/15:10312356
Result on the web
<a href="http://dx.doi.org/10.1016/j.nicl.2015.08.008" target="_blank" >http://dx.doi.org/10.1016/j.nicl.2015.08.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.nicl.2015.08.008" target="_blank" >10.1016/j.nicl.2015.08.008</a>

Result language
angličtina
Original language name
Resting-state functional magnetic resonance imaging of the subthalamic microlesion and stimulation effects in Parkinson's disease : Indications of a principal role of the brainstem
Original language description
During implantation of deep-brain stimulation (DBS) electrodes in the target structure, neurosurgeons and neurologists commonly observe a "microlesion effect" (MLE), which occurs well before initiating subthalamic DBS. This phenomenon typically leads toa transitory improvement of motor symptoms of patients suffering from Parkinson's disease (PD). Mechanisms behind MLE remain poorly understood. In this work, we exploited the notion of ranking to assess spontaneous brain activity in PD patients examinedby resting-state functional magnetic resonance imaging in response to penetration of DBS electrodes in the subthalamic nucleus. In particular, we employed a hypothesis-free method, eigenvector centrality (EC), to reveal motor-communication-hubs of the highest rank and their reorganization following the surgery; providing a unique opportunity to evaluate the direct impact of disrupting the PD motor circuitry in vivo without prior assumptions. Penetration of electrodes was associated with
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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