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Relapses Requiring Intravenous Steroid Use and Multiple-Sclerosis-related Hospitalizations : Integrated Analysis of the Delayed-release Dimethyl Fumarate Phase III Studies

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10313208" target="_blank" >RIV/00216208:11110/15:10313208 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064165:_____/15:10313208

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.clinthera.2015.09.011" target="_blank" >http://dx.doi.org/10.1016/j.clinthera.2015.09.011</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.clinthera.2015.09.011" target="_blank" >10.1016/j.clinthera.2015.09.011</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Relapses Requiring Intravenous Steroid Use and Multiple-Sclerosis-related Hospitalizations : Integrated Analysis of the Delayed-release Dimethyl Fumarate Phase III Studies

  • Original language description

    Purpose The purpose was to report the effects of delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on the number of relapses requiring intravenous (IV) steroids and multiple sclerosis (MS)-related hospitalizations using integrated data from the Phase III DEFINE and CONFIRM studies. Data DEFINE and CONFIRM were pooled and analyzed using a negative binomial regression model (adjusted for study and region). Data obtained after subjects switched to an alternative MS therapy were not included in the analysis. Only relapses confirmed by the Independent Neurology Evaluation Committee were included in the analysis of relapses requiring IV steroids. Findings The study population (intention-to-treat) comprised 2301 patients who receivedeither placebo (n = 771), DMF BID (n = 769), or DMF TID (n = 761). Baseline demographic and disease characteristics were generally well balanced among treatment groups. Throughout the 2-year studies, the total number of relapses treated

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FH - Neurology, neuro-surgery, nuero-sciences

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical Therapeutics

  • ISSN

    0149-2918

  • e-ISSN

  • Volume of the periodical

    37

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    9

  • Pages from-to

    2543-2551

  • UT code for WoS article

    000366242900017

  • EID of the result in the Scopus database

    2-s2.0-84947942315