Treatment of Severe Renal Disease in ANCA Positive and Negative Small Vessel Vasculitis with Rituximab

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10313541" target="_blank" >RIV/00216208:11110/15:10313541 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1159/000431336" target="_blank" >http://dx.doi.org/10.1159/000431336</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000431336" target="_blank" >10.1159/000431336</a>

Result language

angličtina

Original language name

Treatment of Severe Renal Disease in ANCA Positive and Negative Small Vessel Vasculitis with Rituximab

Original language description

Background/Aims: Rituximab and glucocorticoids are a non-inferior alternative to cyclophosphamide and glucocorticoid therapy for induction of remission in antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) patients with moderate renaldisease. The efficacy and safety of this approach in patients with severe renal impairment are unknown. We report the outcomes and safety profile of rituximab and glucocorticoid therapy for induction of remission in patients with AAV and ANCA-negative vasculitis presenting with severe renal disease. Methods: A multicenter, retrospective, cohort study was conducted between 2005 and 2014. Patients with new or relapsing disease with an estimated glomerular filtration rate (eGFR) of <= 20 ml/min/ 1.73 m(2)treated with rituximab and glucocorticoid induction with or without plasmapheresis were included. Fourteen patients met the inclusion criteria. The primary outcomes were rate of remission and dialysis independence at 6 months. The second

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

—

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

American Journal of Nephrology

ISSN

0250-8095

e-ISSN

—

Volume of the periodical

41

Issue of the periodical within the volume

4-5

Country of publishing house

CH - SWITZERLAND

Number of pages

6

Pages from-to

296-301

UT code for WoS article

000358515000005

EID of the result in the Scopus database

2-s2.0-84930532045