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The Role of Steroid Hormones in the Development of Intrahepatic Cholestasis of Pregnancy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10313577" target="_blank" >RIV/00216208:11110/15:10313577 - isvavai.cz</a>

  • Alternative codes found

    RIV/00023761:_____/15:#0000566 RIV/00064165:_____/15:10313577

  • Result on the web

    <a href="http://www.biomed.cas.cz/physiolres/pdf/64/64_S203.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/64/64_S203.pdf</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    The Role of Steroid Hormones in the Development of Intrahepatic Cholestasis of Pregnancy

  • Original language description

    Intrahepatic cholestasis of pregnancy (ICP) is a disorder of liver function, commonly occurring in the third trimester but sometimes also as soon as the end of the second trimester of pregnancy. Symptoms of this disorder include pruritus, plus abnormal values of bile acids and hepatic transaminases. After birth, symptoms disappear and liver function returns to normal. Though ICP is relatively non-complicated and often symptomatically mild from the point-of-view of the mother, it presents a serious riskto the fetus, making this disease the subject of great interest. The etiology and pathogenesis of ICP is multifactorial and as yet not fully elucidated. Hormonal factors likely play a significant role, along with genetic as well as exogenous factors. Here we summarize the knowledge of changes in steroid hormones and their role in the development of intrahepatic cholestasis of pregnancy. In addition, we consider the role of exogenous factors as possible triggers of steroid hormone changes

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FB - Endocrinology, diabetology, metabolism, nutrition

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NT12211" target="_blank" >NT12211: Prediction of termination of pregnancy in women with serious hepatopathies</a><br>

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Physiological Research

  • ISSN

    0862-8408

  • e-ISSN

  • Volume of the periodical

    64

  • Issue of the periodical within the volume

    Supplement 2

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    7

  • Pages from-to

    "S203"-"S209"

  • UT code for WoS article

    000365011800014

  • EID of the result in the Scopus database

    2-s2.0-84952655118