Pancreatic Cancer Diagnostics and Treatment - Current State

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10314590" target="_blank" >RIV/00216208:11110/15:10314590 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/15:10314590

Result on the web

<a href="http://pmr.lf1.cuni.cz/media/pdf/pmr_2015116040253.pdf" target="_blank" >http://pmr.lf1.cuni.cz/media/pdf/pmr_2015116040253.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14712/23362936.2015.65" target="_blank" >10.14712/23362936.2015.65</a>

Result language

angličtina

Original language name

Pancreatic Cancer Diagnostics and Treatment - Current State

Original language description

Pancreatic ductal adenocarcinoma (PDAC) represents permanent and ever rising issue worldwide. Five-year survival does not exceed 3 to 6%, i.e. the worst result among solid tumours. The article evaluates the current state of PDAC diagnostics and treatmentspecifying also development and trends. Percentage of non-resectable tumours due to locally advanced or metastatic condition varies 60-80%, mostly over 80%. Survival with non-resectable PDAC is 4 to 8 months (median 3.5). In contrast R0 resection showsthe survival 18-27 months. Laboratory and imaging screening methods are not indicated on large scale. Risk factors are smoking, alcohol abuse, chronic pancreatitis, diabetes mellitus. Genetic background in most PDAC has not been detected yet. Some genesconnected with high risk of PDAC (e.g. BRCA2, PALB2) have been identified as significant and highly penetrative, but link between PDAC and these genes can be seen only in 10-20%. This article surveys perspective oncogenes, tumour suppress

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Prague medical report

ISSN

1214-6994

e-ISSN

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Volume of the periodical

116

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

15

Pages from-to

253-267

UT code for WoS article

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EID of the result in the Scopus database

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