Incident and prevalent cohorts with pulmonary arterial hypertension: insight from SERAPHIN
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10314959" target="_blank" >RIV/00216208:11110/15:10314959 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/15:10314959
Result on the web
<a href="http://dx.doi.org/10.1183/13993003.00364-2015" target="_blank" >http://dx.doi.org/10.1183/13993003.00364-2015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1183/13993003.00364-2015" target="_blank" >10.1183/13993003.00364-2015</a>
Alternative languages
Result language
angličtina
Original language name
Incident and prevalent cohorts with pulmonary arterial hypertension: insight from SERAPHIN
Original language description
In SERAPHIN, a long-term, randomised, controlled trial (NCT00660179) in pulmonary arterial hypertension (PAH), macitentan significantly reduced the risk of morbidity/mortality and PAH-related death/hospitalisation. We evaluated disease progression and the effect of macitentan in treatment-nave incident and prevalent cohorts. Patients allocated to placebo, or macitentan 3 mg or 10 mg were classified by time from diagnosis to enrolment as incident (<= 6 months; n=110) or prevalent (>6 months; n=157). Therisk of morbidity/mortality and PAH-related death/hospitalisation was determined using Cox regression. The risk of morbidity/mortality (Kaplan-Meier estimates at month 12: 54.4% versus 26.7%; p=0.006) and PAH-related death/hospitalisation (Kaplan-Meier estimates at month 12: 47.3% versus 19.9%; p=0.006) were significantly higher for incident versus prevalent patients receiving placebo, respectively. There was no significant difference in the risk of all-cause death between incident and p
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
—
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Respiratory Journal
ISSN
0903-1936
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
1711-1720
UT code for WoS article
000366948700025
EID of the result in the Scopus database
2-s2.0-84949032805