Drugs related to monoamine oxidase activity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10325511" target="_blank" >RIV/00216208:11110/16:10325511 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.pnpbp.2016.02.012" target="_blank" >http://dx.doi.org/10.1016/j.pnpbp.2016.02.012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pnpbp.2016.02.012" target="_blank" >10.1016/j.pnpbp.2016.02.012</a>

Result language

angličtina

Original language name

Drugs related to monoamine oxidase activity

Original language description

Progress in understanding the role of monoamine neurotransmission in pathophysiology of neuropsychiatric disorders was made after the discovery of the mechanisms of action of psychoactive drugs, including monoamine oxidase (MAO) inhibitors. The increase in monoamine neurotransmitter availability, decrease in hydrogen peroxide production, and neuroprotective effects evoked by MAO inhibitors represent an important approach in the development of new drugs for the treatment of mental disorders and neurodegenerative diseases. New drugs are synthesized by acting asmultitarget-directed ligands, with MAO, acetylcholinesterase, and iron chelation as targets. Basic information is summarized in this paper about the drug-induced regulation of monoaminergic systems in the brain, with a focus on MAO inhibition. Desirable effects of MAO inhibition include increased availability of monoamine neurotransmitters, decreased oxidative stress, decreased formation of neurotoxins, induction of pro-survival genes and antiapoptotic factors, and improved mitochondrial functions.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

—

Project

<a href="/en/project/NV15-28967A" target="_blank" >NV15-28967A: Modulators of mitochondrial enzymes for treatment of neurodegenerative disorders</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Progress in Neuro-Psychopharmacology and Biological Psychiatry

ISSN

0278-5846

e-ISSN

—

Volume of the periodical

69

Issue of the periodical within the volume

August

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

112-124

UT code for WoS article

000376204500013

EID of the result in the Scopus database

2-s2.0-84959924226