Histological Assessment of a Combined Low-Level Laser/Light-Emitting Diode Therapy (685 nm/470 nm) for Sutured Skin Incisions in a Porcine Model: A Short Report
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10326142" target="_blank" >RIV/00216208:11110/16:10326142 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1089/pho.2015.4013" target="_blank" >http://dx.doi.org/10.1089/pho.2015.4013</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/pho.2015.4013" target="_blank" >10.1089/pho.2015.4013</a>
Alternative languages
Result language
angličtina
Original language name
Histological Assessment of a Combined Low-Level Laser/Light-Emitting Diode Therapy (685 nm/470 nm) for Sutured Skin Incisions in a Porcine Model: A Short Report
Original language description
Objective: The aim of our study was to evaluate, from a histological point of view, the effect of photo-biomodulation (PBM) with combined low- level laser therapy (LLLT)/light-emitting diode (LED) on porcine skin wound healing. Background data: Most LLLT/LED wound healing studies have been performed on various types of rat models, with their inherent limitations. Minipigs are evolutionary and physiologically closer to humans than rats. Materials and methods: With the animals under general anesthesia, one full-thickness skin incision was performed on the back of each minipig (n = 10) and immediately closed using simple interrupted percutaneous sutures. The minipigs were randomly allocated into two groups: a PBM-treated group (LLLT lambda = 685 nm, LED lambda = 470 nm, both light sources producing power densities at 0.008 W/cm(2); each light source delivering total daily doses of 3.36 J/cm(2)) and a sham-irradiated control group. Half of the animals in each group were killed on postoperative day 3, and the other half were killed on the postoperative day 7, and samples were removed for histological examination. Results: Combined red and blue PBM accelerated the process of reepithelization and formation of cross-linked collagen fibers compared with sham irradiated control wounds. Conclusions: Our results demonstrate that the current dose of combined red and blue PBM improves the healing of sutured skin incisions in minipigs.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FJ - Surgery including transplantology
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Photomedicine and Laser Surgery
ISSN
1549-5418
e-ISSN
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Volume of the periodical
34
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
53-60
UT code for WoS article
000375269900002
EID of the result in the Scopus database
2-s2.0-84957681314