Benzodiazepines, Age-Related Pharmacological Changes, and Risk of Falls in Older Adults
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10336688" target="_blank" >RIV/00216208:11110/16:10336688 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/16:10336688
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/B9780128006344000330" target="_blank" >http://www.sciencedirect.com/science/article/pii/B9780128006344000330</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-800634-4.00033-0" target="_blank" >10.1016/B978-0-12-800634-4.00033-0</a>
Alternative languages
Result language
angličtina
Original language name
Benzodiazepines, Age-Related Pharmacological Changes, and Risk of Falls in Older Adults
Original language description
Benzodiazepines belong to the group of hypnosedative medications. They are commonly prescribed for anxiety disorders and sleep problems and are widely used in younger adults as well as in the older population. However, their pharmacological profile can be influenced by age-related changes in pharmacokinetics and pharmacodynamics resulting in an increased potential to cause adverse effects such as daily sleepiness, fatigue, falls, cognitive impairment, and confusion. Falls in older people are described as multifactorial adverse events, with use of particular medications being one of the potential risk factors. Despite extensive evaluation of benzodiazepines' contribution to falls in older patients, the research yielded mixed results, and differences between particular drugs or dosage regimens remain questionable. Risk/benefit ratios of particular active substances in the group of benzodiazepines, their cautious indication for specific problems and rational selection, particularly in older adults with various multiple comorbidities, should be carefully evaluated in daily clinical practice.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Neuropathology of Drug Addictions and Substance Misuse: Volume 3
ISBN
978-0-12-800634-4
Number of pages of the result
11
Pages from-to
334-344
Number of pages of the book
1106
Publisher name
Elsevier
Place of publication
Amsterdam
UT code for WoS chapter
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