Focal osteoporosis defects play a key role in hip fracture
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10332262" target="_blank" >RIV/00216208:11110/17:10332262 - isvavai.cz</a>
Alternative codes found
RIV/00064211:_____/17:W0000046 RIV/00023884:_____/12:00007498 RIV/00023728:_____/17:N0000043
Result on the web
<a href="http://dx.doi.org/10.1016/j.bone.2016.10.020" target="_blank" >http://dx.doi.org/10.1016/j.bone.2016.10.020</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bone.2016.10.020" target="_blank" >10.1016/j.bone.2016.10.020</a>
Alternative languages
Result language
angličtina
Original language name
Focal osteoporosis defects play a key role in hip fracture
Original language description
Background: Hip fractures are mainly caused by accidental falls and trips, which magnify forces in well-defined areas of the proximal femur. Unfortunately, the same areas are at risk of rapid bone loss with ageing, since they are relatively stress-shielded during walking and sitting. Focal osteoporosis in those areas may contribute to fracture, and targeted 3D measurements might enhance hip fracture prediction. In the FEMCO case-control clinical study, Cortical Bone Mapping (CBM) was applied to clinical computed tomography (CT) scans to define 3D cortical and trabecular bone defects in patients with acute hip fracture compared to controls. Direct measurements of trabecular bone volume were then made in biopsies of target regions removed at operation. Methods: The sample consisted of CT scans from 313 female and 40 male volunteers (158 with proximal femoral fracture, 145 age-matched controls and 50 fallers without hip fracture). Detailed Cortical Bone Maps (c.5580 measurement points on the unfractured hip) were created before registering each hip to an average femur shape to facilitate statistical parametric mapping (SPM). Areas where cortical and trabecular bone differed from controls were visualised in 3D for location, magnitude and statistical significance. Measures from the novel regions created by the SPM process were then tested for their ability to classify fracture versus control by comparison with traditional CT measures of areal Bone Mineral Density (aBMD). In women we used the surgical classification of fracture location ('femoral neck' or 'trochanteric') to discover whether focal osteoporosis was specific to fracture type. To explore whether the focal areas were osteoporotic by histological criteria, we used micro CT to measure trabecular bone parameters in targeted biopsies taken from the femoral heads of 14 cases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30211 - Orthopaedics
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bone
ISSN
8756-3282
e-ISSN
—
Volume of the periodical
94
Issue of the periodical within the volume
January
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
124-134
UT code for WoS article
000389283000016
EID of the result in the Scopus database
2-s2.0-84993929547