Antipsychotic Drug Interactions and Mortality Among Nursing Home Residents With Cognitive Impairment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10361876" target="_blank" >RIV/00216208:11110/17:10361876 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.4088/JCP.15m10303" target="_blank" >http://dx.doi.org/10.4088/JCP.15m10303</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4088/JCP.15m10303" target="_blank" >10.4088/JCP.15m10303</a>

Result language

angličtina

Original language name

Antipsychotic Drug Interactions and Mortality Among Nursing Home Residents With Cognitive Impairment

Original language description

Objective: Among elderly individuals with dementia, the use of antipsychotics has been associated with serious adverse events including ischemic stroke and death. Multiple medications can interact with antipsychotics and increase the risk of such adverse events. The purpose of this retrospective, longitudinal cohort study was to estimate the prevalence of potential antipsychotic drug interactions and their effect on increasing the risk of death among cognitively impaired elderly individuals treated with antipsychotics. Methods: We conducted a retrospective longitudinal cohort study in 59 nursing homes of 7 European Union countries and Israel. The study was conducted during the years 2009 to 2011. Participants were cognitively impaired individuals aged 65 years or older residing in the participating nursing homes and being treated with antipsychotics (N = 604). Risk of death associated with potential antipsychotic drug interactions was the main outcome. The inter-Resident Assessment Instrument for Long Term Care Facilities (interRAI LTCF) was used to assess participants. Follow-up time was 12 months. Conclusions: Part of the observed excess risk of death associated with the use of antipsychotic medications in elderly individuals with cognitive impairment may be attributable to antipsychotic drug interactions. Antipsychotics should be used with extreme caution especially among those individuals receiving concomitant cardiovascular or psychotropic medications.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30227 - Geriatrics and gerontology

Project

<a href="/en/project/7E12078" target="_blank" >7E12078: A randomized clinical trial to evaluate the effectiveness of a multi-modal intervention in older people with type 2 diatebes on frailty and quality of life: The MID-FRAIL Study</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Clinical Psychiatry

ISSN

0160-6689

e-ISSN

—

Volume of the periodical

78

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

"E76"-"E82"

UT code for WoS article

000396330600011

EID of the result in the Scopus database

2-s2.0-85012934978