Haemodynamic effects of riociguat in inoperable/recurrent chronic thromboembolic pulmonary hypertension

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10362244" target="_blank" >RIV/00216208:11110/17:10362244 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/17:10362244

Result on the web

<a href="http://dx.doi.org/10.1136/heartjnl-2016-309621" target="_blank" >http://dx.doi.org/10.1136/heartjnl-2016-309621</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/heartjnl-2016-309621" target="_blank" >10.1136/heartjnl-2016-309621</a>

Result language

angličtina

Original language name

Haemodynamic effects of riociguat in inoperable/recurrent chronic thromboembolic pulmonary hypertension

Original language description

Objective We compared the haemodynamic effects of riociguat in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) or persistent/recurrent CTEPH after pulmonary endarterectomy in the Chronic Thromboembolic Pulmonary Hypertension Soluble Guanylate CyclaseStimulator Trial 1 study. Methods Patients with inoperable or persistent/recurrent CTEPH (n= 261; mean +/- SD age 59 +/- 14 years; 66% women) were randomised to riociguat (up to 2.5 mg three times daily) or placebo. Haemodynamic parameters were assessed at baseline and week 16. Results Riociguat decreased pulmonary vascular resistance (PVR) in inoperable (n= 189; least-squares mean difference: -285 dyn s/cm(5) (95% CI -357 to -213); p&lt; 0.0001) and persistent/recurrent (n= 72; -131 dyn s/cm(5) (95% CI -214 to -48); p= 0.0025) patients. Cardiac index improved in inoperable patients by a least-squares mean difference of + 0.6 L/min/m(2) (95% CI 0.4 to 0.7; p&lt; 0.0001), while in persistent/recurrent patients the change was + 0.2 L/min/m(2) (95% CI -0.1 to 0.5; p= 0.17). Mean pulmonary artery pressure decreased in inoperable and persistent/recurrent patients(-4.7 mm Hg (95% CI -6.9 to -2.6; p&lt; 0.0001 and -4.8 mm Hg (-8.2 to -1.5; p= 0.0055), respectively). For all patients, changes in 6 min walk distance correlated with changes in PVR (r=-0.29 (95% CI -0.41 to -0.17); p&lt; 0.0001) and cardiac index (r= 0.23 (95% CI 0.10 to 0.35); p= 0.0004). Conclusions Riociguat improved haemodynamics in patients with inoperable CTEPH or persistent/recurrent CTEPH.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Heart

ISSN

1355-6037

e-ISSN

—

Volume of the periodical

103

Issue of the periodical within the volume

8

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

599-606

UT code for WoS article

000398196000010

EID of the result in the Scopus database

2-s2.0-85007553221