NETosis provides the link between activation of neutrophils on hemodialysis membrane and comorbidities in dialyzed patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10362253" target="_blank" >RIV/00216208:11110/17:10362253 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/17:10362253

Result on the web

<a href="http://dx.doi.org/10.1007/s00011-016-1010-6" target="_blank" >http://dx.doi.org/10.1007/s00011-016-1010-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00011-016-1010-6" target="_blank" >10.1007/s00011-016-1010-6</a>

Result language

angličtina

Original language name

NETosis provides the link between activation of neutrophils on hemodialysis membrane and comorbidities in dialyzed patients

Original language description

Introduction: Neutrophil extracellular traps (NETs) are formed by activated neutrophils during the process of NETosis in which the nuclear material is released into extracellular space, including DNA molecules, citrullinated histones, and neutrophil granule enzymes, such as elastase. This material forms networks that are able not only to physically entrap bacteria but also to provide elevated concentration of bactericidal components. Over the last years, it has become clear that NETs can also be formed under numerous sterile inflammatory conditions, i.e., thrombosis, cancer, SLE, atherosclerosis, and diabetes. Method: We reviewed studies published until July 2016 to find possible associations between elevated cell-free DNA levels in dialyzed patients and the process of NETosis and its consequences. Results: The process of NETosis, its elevated activation, or impaired clearance provides the link between clinical conditions and elevated levels of cell-free DNA found in plasma after the hemodialytic procedure which itself is able to activate neutrophils via platelets and ROS formation. NETs stimulate thrombosis and endothelial damage, and their formation may contribute to the development of spectrum of comorbidities described in dialyzed patients. Conclusion: The study of plasma cell-free DNA levels together with markers of NETosis could contribute to the evaluation of the influence of hemodialysis on the immune system of patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30217 - Urology and nephrology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Inflammation Research

ISSN

1023-3830

e-ISSN

—

Volume of the periodical

66

Issue of the periodical within the volume

5

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

369-378

UT code for WoS article

000399170100002

EID of the result in the Scopus database

2-s2.0-84996636516