Optical probes and sensors as perspective tools in epigenetics

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10362289" target="_blank" >RIV/00216208:11110/17:10362289 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.bmc.2017.01.011" target="_blank" >http://dx.doi.org/10.1016/j.bmc.2017.01.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bmc.2017.01.011" target="_blank" >10.1016/j.bmc.2017.01.011</a>

Result language

angličtina

Original language name

Optical probes and sensors as perspective tools in epigenetics

Original language description

Modifications of DNA cytosine bases and histone posttranslational modifications play key roles in the control of gene expression and specification of cell states. Such modifications affect many important biological processes and changes to these important regulation mechanisms can initiate or significantly contribute to the development of many serious pathological states. Therefore, recognition and determination of chromatin modifications is an important goal in basic and clinical research. Two of the most promising tools for this purpose are optical probes and sensors, especially colourimetric and fluorescence devices. The use of optical probes and sensors is simple, without highly expensive instrumentation, and with excellent sensitivity and specificity for target structural motifs. Accordingly, the application of various probes and sensors in the recognition and determination of cytosine modifications and structure of his tones and histone posttranslational modifications, are discussed in detail in this review.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10401 - Organic chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioorganic &amp; Medicinal Chemistry

ISSN

0968-0896

e-ISSN

—

Volume of the periodical

25

Issue of the periodical within the volume

8

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

2295-2306

UT code for WoS article

000399437100001

EID of the result in the Scopus database

2-s2.0-85014801351