Human polyomavirus 6 and 7 are associated with pruritic and dyskeratotic dermatoses

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10363704" target="_blank" >RIV/00216208:11110/17:10363704 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/17:10363704

Result on the web

<a href="http://dx.doi.org/10.1016/j.jaad.2016.11.035" target="_blank" >http://dx.doi.org/10.1016/j.jaad.2016.11.035</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jaad.2016.11.035" target="_blank" >10.1016/j.jaad.2016.11.035</a>

Result language

angličtina

Original language name

Human polyomavirus 6 and 7 are associated with pruritic and dyskeratotic dermatoses

Original language description

Background: Human polyomavirus (HPyV) 6 and HPyV7 are shed chronically from human skin. HPyV7, but not HPyV6, has been linked to a pruritic skin eruption of immunosuppression. Objective: We determined whether biopsy specimens showing a characteristic pattern of dyskeratosis and parakeratosis might be associated with polyomavirus infection. Methods: We screened biopsy specimens showing &quot;peacock plumage&apos;&apos; histology by polymerase chain reaction for HPyVs. Cases positive for HPyV6 or HPyV7 were then analyzed by immunohistochemistry, electron microscopy, immunofluorescence, quantitative polymerase chain reaction, and complete sequencing, including unbiased, next-generation sequencing. Results: We identified 3 additional cases of HPyV6 or HPyV7 skin infections. Expression of T antigen and viral capsid was abundant in lesional skin. Dual immunofluorescence staining experiments confirmed that HPyV7 primarily infects keratinocytes. High viral loads in lesional skin compared with normal-appearing skin and the identification of intact virions by both electron microscopy and next-generation sequencing support a role for active viral infections in these skin diseases. Limitation: This was a small case series of archived materials. Conclusion: We have found that HPyV6 and HPyV7 are associated with rare, pruritic skin eruptions with a distinctive histologic pattern and describe this entity as &quot;HPyV6-and HPyV7-associated pruritic and dyskeratotic dermatoses.&apos;&apos;

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30216 - Dermatology and venereal diseases

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the American Academy of Dermatology

ISSN

0190-9622

e-ISSN

—

Volume of the periodical

76

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

932-940

UT code for WoS article

000399217200037

EID of the result in the Scopus database

2-s2.0-85009380248