"No evident disease activity": The use of combined assessments in the management of patients with multiple sclerosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10363755" target="_blank" >RIV/00216208:11110/17:10363755 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/17:10363755
Result on the web
<a href="http://dx.doi.org/10.1177/1352458517703193" target="_blank" >http://dx.doi.org/10.1177/1352458517703193</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/1352458517703193" target="_blank" >10.1177/1352458517703193</a>
Alternative languages
Result language
angličtina
Original language name
"No evident disease activity": The use of combined assessments in the management of patients with multiple sclerosis
Original language description
Using combined endpoints to define no evident disease activity (NEDA) is becoming increasingly common when setting targets for treatment outcomes in multiple sclerosis (MS). Historically, NEDA has taken account of the occurrence of relapses, brain magnetic resonance imaging (MRI) lesions and disability worsening, but this approach places emphasis on inflammatory activity in the brain and mostly overlooks ongoing neurodegenerative damage. Combined assessments of NEDA which take account of changes in brain volume or neuropsychological outcomes such as cognitive function may begin to address this imbalance, and such assessments may also consider blood or spinal-fluid neurofilament levels or patient-reported outcomes and quality of life measures. If a combined NEDA assessment can be validated in prospective studies as indicative of long-term disease remission at the individual patient level, treating to achieve NEDA could become the goal of clinical practice and achieving NEDA may become the "new normal" state of disease control for patients with MS
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Multiple Sclerosis Journal
ISSN
1352-4585
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
1179-1187
UT code for WoS article
000406386600003
EID of the result in the Scopus database
2-s2.0-85026670884