Prospective study of thrombosis and thrombospondin-1 expression in Chuvash polycythemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10363950" target="_blank" >RIV/00216208:11110/17:10363950 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3324/haematol.2016.158170" target="_blank" >http://dx.doi.org/10.3324/haematol.2016.158170</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3324/haematol.2016.158170" target="_blank" >10.3324/haematol.2016.158170</a>

Result language

angličtina

Original language name

Prospective study of thrombosis and thrombospondin-1 expression in Chuvash polycythemia

Original language description

In Chuvash polycythemia (CP), homozygous germline VHLR200W results in augmented hypoxia sensing, elevated erythropoietin and hemoglobin, and increased morbidity and mortality from thrombosis, but the relative risks and molecular basis have not been prospectively evaluated.1-3 We enrolled 128 CP adults and 128 controls from Russia&apos;s Chuvash Republic in an observational study from 2005-2009, in order to prospectively define the risk of complications and to provide mechanistic insights. We hypothesized that variation in the expression of hypoxia inducible factor (HIF)-regulated genes may contribute to increased thrombosis. During a median follow up of 8.8-years, CP was associated with a 9.6-fold increase in the rate of new thrombosis compared to controls, after adjustment for significant risk factors such as age and smoking. The probability of new thrombosis in CP did not increase with higher baseline hemoglobin concentration, but it increased with age, smoking, baseline therapeutic phlebotomy and higher expressions of THBS1, CXCL2 and EREG.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30205 - Hematology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Haematologica

ISSN

0390-6078

e-ISSN

—

Volume of the periodical

102

Issue of the periodical within the volume

5

Country of publishing house

IT - ITALY

Number of pages

4

Pages from-to

"E166"-"E169"

UT code for WoS article

000402490900002

EID of the result in the Scopus database

2-s2.0-85019001582