Relationship between serum calprotectin (S100A8/9) and clinical, laboratory and ultrasound parameters of disease activity in rheumatoid arthritis: A large cohort study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364443" target="_blank" >RIV/00216208:11110/17:10364443 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11510/17:10364443 RIV/00023728:_____/17:N0000079

Result on the web

<a href="http://dx.doi.org/10.1371/journal.pone.0183420" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0183420</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0183420" target="_blank" >10.1371/journal.pone.0183420</a>

Result language

angličtina

Original language name

Relationship between serum calprotectin (S100A8/9) and clinical, laboratory and ultrasound parameters of disease activity in rheumatoid arthritis: A large cohort study

Original language description

Background Calprotectin may be a sensitive biomarker of rheumatoid arthritis (RA) disease activity. Objectives In the current study, we investigated whether calprotectin is a better biomarker than CRP for predicting clinical activity and ultrasound parameters in patients with RA. Methods A total of 160 patients with RA underwent clinical (swollen joint count-SJC, tender joint count-TJC, Disease Activity Score-DAS28, Clinical Disease Activity Index-CDAI, and simplified Disease Activity Index-SDAI) and ultrasound (German US7) examination. Clinical and laboratory measures were correlated with ultrasound findings using Spearman&apos;s correlation coefficient. Differences in serum calprotectin levels in patients with variable disease activity according to the DAS28-ESR and CDAI scores were assessed using ANOVA. Multivariate regression analysis was used to determine the predictive values of calprotectin, CRP and SJC for CDAI and PD US synovitis scores. Results Serum calprotectin was significantly associated with DAS28-ESR (r = 0.321, p&lt;0.001), DAS28-CRP (r = 0.346, p&lt;0.001), SDAI (r = 0.305, p&lt;0.001), CDAI (r = 0.279, p&lt;0.001) scores and CRP levels (r = 0.556, p&lt;0.001). Moreover, calprotectin was significantly correlated with GS (r = 0.379, p&lt;0.001) and PD synovitis scores (r = 0.419, p&lt;0.001). The multi-variate regression analysis showed that calprotectin is a better predictor of the CDAI score and PD US synovitis than CRP. Conclusions The results of this study support an additional role of calprotectin in assessing inflammatory activity in patients with RA.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30226 - Rheumatology

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS One

ISSN

1932-6203

e-ISSN

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Volume of the periodical

12

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

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UT code for WoS article

000408355800058

EID of the result in the Scopus database

2-s2.0-85028442983