Effect of Pulsatility on Microcirculation in Patients Treated with Extracorporeal Cardiopulmonary Resuscitation: A Pilot Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364447" target="_blank" >RIV/00216208:11110/17:10364447 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21730/17:00320088 RIV/00064203:_____/17:10364447 RIV/00064165:_____/17:10364447
Result on the web
<a href="http://dx.doi.org/10.1097/MAT.0000000000000492" target="_blank" >http://dx.doi.org/10.1097/MAT.0000000000000492</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/MAT.0000000000000492" target="_blank" >10.1097/MAT.0000000000000492</a>
Alternative languages
Result language
angličtina
Original language name
Effect of Pulsatility on Microcirculation in Patients Treated with Extracorporeal Cardiopulmonary Resuscitation: A Pilot Study
Original language description
The effect of pulsatile blood flow on microcirculation during extracorporeal cardiopulmonary resuscitation (ECPR) is not elucidated; therefore, we designed an observational study comparing sublingual microcirculation in patients with refractory cardiac arrest (CA) with spontaneously pulsatile or low/nonpulsatile blood flow after treatment with ECPR. Microcirculation was assessed with Sidestream Dark Field technology in 12 patients with CA who were treated with ECPR and 12 healthy control subjects. Microcirculatory images were analyzed offline in a blinded fashion, and consensual parameters were determined for the vessels <= 20 mu m. The patients' data, including actual hemodynamic parameters, were documented. Pulsatile blood flow was defined by a pulse pressure (PP) >= 15 mm Hg. Compared with the healthy volunteers, the patients who were treated with ECPR exhibited a significantly lower proportion of perfused capillaries (PPC); other microcirculatory parameters did not differ. The groups of patients with pulsatile (n = 7) versus low/nonpulsatile (n = 5) blood flow did not differ in regards to the collected data and hemodynamic variables (except for the PP and ejection fraction of the left ventricle) as well as microcirculatory parameters. In conclusion, microcirculation appeared to be effectively supported by ECPR in our group of patients with CA with the exception of the PPC. We found only nonsignificant contribution of spontaneous pulsatility to extracorporeal membrane oxygenation-generated microcirculatory blood flow.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NT13225" target="_blank" >NT13225: Hyperinvasive approach to out-of hospital cardiac arrest using mechanical chest compression, prehospital cooling, extracorporeal life support and early invasive assessment compared to standard of care. A randomized comparative study. "Prague OHCA study"</a><br>
Continuities
O - Projekt operacniho programu
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ASAIO Journal
ISSN
1058-2916
e-ISSN
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Volume of the periodical
63
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
386-391
UT code for WoS article
000408848900007
EID of the result in the Scopus database
2-s2.0-85021872899