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Effect of Pulsatility on Microcirculation in Patients Treated with Extracorporeal Cardiopulmonary Resuscitation: A Pilot Study

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364447" target="_blank" >RIV/00216208:11110/17:10364447 - isvavai.cz</a>

  • Alternative codes found

    RIV/68407700:21730/17:00320088 RIV/00064203:_____/17:10364447 RIV/00064165:_____/17:10364447

  • Result on the web

    <a href="http://dx.doi.org/10.1097/MAT.0000000000000492" target="_blank" >http://dx.doi.org/10.1097/MAT.0000000000000492</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1097/MAT.0000000000000492" target="_blank" >10.1097/MAT.0000000000000492</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effect of Pulsatility on Microcirculation in Patients Treated with Extracorporeal Cardiopulmonary Resuscitation: A Pilot Study

  • Original language description

    The effect of pulsatile blood flow on microcirculation during extracorporeal cardiopulmonary resuscitation (ECPR) is not elucidated; therefore, we designed an observational study comparing sublingual microcirculation in patients with refractory cardiac arrest (CA) with spontaneously pulsatile or low/nonpulsatile blood flow after treatment with ECPR. Microcirculation was assessed with Sidestream Dark Field technology in 12 patients with CA who were treated with ECPR and 12 healthy control subjects. Microcirculatory images were analyzed offline in a blinded fashion, and consensual parameters were determined for the vessels &lt;= 20 mu m. The patients&apos; data, including actual hemodynamic parameters, were documented. Pulsatile blood flow was defined by a pulse pressure (PP) &gt;= 15 mm Hg. Compared with the healthy volunteers, the patients who were treated with ECPR exhibited a significantly lower proportion of perfused capillaries (PPC); other microcirculatory parameters did not differ. The groups of patients with pulsatile (n = 7) versus low/nonpulsatile (n = 5) blood flow did not differ in regards to the collected data and hemodynamic variables (except for the PP and ejection fraction of the left ventricle) as well as microcirculatory parameters. In conclusion, microcirculation appeared to be effectively supported by ECPR in our group of patients with CA with the exception of the PPC. We found only nonsignificant contribution of spontaneous pulsatility to extracorporeal membrane oxygenation-generated microcirculatory blood flow.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

    <a href="/en/project/NT13225" target="_blank" >NT13225: Hyperinvasive approach to out-of hospital cardiac arrest using mechanical chest compression, prehospital cooling, extracorporeal life support and early invasive assessment compared to standard of care. A randomized comparative study. "Prague OHCA study"</a><br>

  • Continuities

    O - Projekt operacniho programu

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    ASAIO Journal

  • ISSN

    1058-2916

  • e-ISSN

  • Volume of the periodical

    63

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

    386-391

  • UT code for WoS article

    000408848900007

  • EID of the result in the Scopus database

    2-s2.0-85021872899