Circulating tumor DNA detection in head and neck cancer: evaluation of two different detection approaches

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364612" target="_blank" >RIV/00216208:11110/17:10364612 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.18632/oncotarget.20004" target="_blank" >http://dx.doi.org/10.18632/oncotarget.20004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.18632/oncotarget.20004" target="_blank" >10.18632/oncotarget.20004</a>

Result language

angličtina

Original language name

Circulating tumor DNA detection in head and neck cancer: evaluation of two different detection approaches

Original language description

The use of non-invasive biomarkers such as circulating tumor DNA (ctDNA) in head and neck tumors may be of relevance in early diagnosis and eventually improved outcome. We evaluated two different approaches from two case series in Europe and South America including (i) targeted screening of ctDNA mutations, and (ii) detection of TP53 mutations in plasma and oral rinses without previous knowledge of mutational status in tumor samples. Targeted sequencing in 5 genes identified ctDNA mutations in plasma among 42% of HNSCC cases, 67% of who were early stage cases. No association was found between ctDNA mutation detection and overall survival. Sequencing of the entire coding region of the TP53 gene resulted in identification of TP53 mutations in 76% of tumor cases. However, concordance of mutation detection was low between tumor, oral rinses (11%) and plasma (2,7%) samples. Identification of 5 pathogenic TP53 mutations in oral rinses from 3 non-cancer controls gives additional evidence of mutation occurrence in individuals without a diagnosed cancer and presents an additional challenge for the development of ctDNA diagnostic assays.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncotarget

ISSN

1949-2553

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

42

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

72621-72632

UT code for WoS article

000411509400102

EID of the result in the Scopus database

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