Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364683" target="_blank" >RIV/00216208:11110/17:10364683 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/17:10364683
Result on the web
<a href="http://dx.doi.org/10.1053/j.gastro.2017.06.002" target="_blank" >http://dx.doi.org/10.1053/j.gastro.2017.06.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1053/j.gastro.2017.06.002" target="_blank" >10.1053/j.gastro.2017.06.002</a>
Alternative languages
Result language
angličtina
Original language name
Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice
Original language description
Background & Aims: The guidelines of the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition allow for diagnosis of celiac disease without biopsies in children with symptoms and levels of immunoglobulin A against tissue-transglutaminase (TGA-IgA) 10-fold or more the upper limit of normal (ULN), confirmed by detection of endomysium antibodies (EMA) and positivity for HLA-DQ2/DQ8. We performed a large, international prospective study to validate this approach. Conclusions: Children can be accurately diagnosed with celiac disease without biopsy analysis. Diagnosis based on level of TGA-IgA 10-fold or more the ULN, a positive result from the EMA tests in a second blood sample, and the presence of at least 1 symptom could avoid risks and costs of endoscopy for more than half the children with celiac disease worldwide. HLA analysis is not required for accurate diagnosis. Clinical Trial Registration no: DRKS00003555.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Gastroenterology
ISSN
0016-5085
e-ISSN
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Volume of the periodical
153
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
924-935
UT code for WoS article
000411835200022
EID of the result in the Scopus database
2-s2.0-85031674147