Inflammatory bowel disease and gastrointestinal malignancies - risks, incidence and management

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10365172" target="_blank" >RIV/00216208:11110/17:10365172 - isvavai.cz</a>

Result on the web

<a href="http://www.prolekare.cz/linkout/62075" target="_blank" >http://www.prolekare.cz/linkout/62075</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amgh2017388" target="_blank" >10.14735/amgh2017388</a>

Result language

angličtina

Original language name

Inflammatory bowel disease and gastrointestinal malignancies - risks, incidence and management

Original language description

Inflammatory bowel disease (IBD) is characterized as an immunomediated chronic inflammation in Crohn&apos;s disease and ulcerative colitis. Although the exact cause of IBD is not entirely clear, an abnormal reaction of the immune system towards physiological microbiota in the colon and small bowel is suspected. IBD has long been associated with an increased risk of malignancies. The main risk is IBD-associated colorectal cancer, which is caused by chronic inflammation, followed by other cancers (including extraintestinal cancers) that develop as a result of the inflammation and subsequent treatment with immunosuppressors/ /biologics. Recent advances in immunosuppressive therapies have significantly improved prognosis as well as quality of life of IBD patients. However, longer survival means prolonged exposure to chronic inflammation as well as to immunosupression (biologics), which translates into a higher risk of cancer development. Therefore, in addition to anti-inflammatory therapies, current strategies for the management of IBD patients also include cancer prevention and surgery, systemic therapy, radiotherapy, and hormonal therapy. The current paper describes the major risk factors of malignancy in IBD patients, and provides an overview of the most commonly occurring IBD-associated gastrointestinal cancers and their management.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30219 - Gastroenterology and hepatology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Gastroenterologie a hepatologie

ISSN

1804-7874

e-ISSN

—

Volume of the periodical

71

Issue of the periodical within the volume

5

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

388-393

UT code for WoS article

—

EID of the result in the Scopus database

2-s2.0-85035787004