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Inflammatory bowel disease and gastrointestinal malignancies - risks, incidence and management

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10365172" target="_blank" >RIV/00216208:11110/17:10365172 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.prolekare.cz/linkout/62075" target="_blank" >http://www.prolekare.cz/linkout/62075</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.14735/amgh2017388" target="_blank" >10.14735/amgh2017388</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Inflammatory bowel disease and gastrointestinal malignancies - risks, incidence and management

  • Original language description

    Inflammatory bowel disease (IBD) is characterized as an immunomediated chronic inflammation in Crohn&apos;s disease and ulcerative colitis. Although the exact cause of IBD is not entirely clear, an abnormal reaction of the immune system towards physiological microbiota in the colon and small bowel is suspected. IBD has long been associated with an increased risk of malignancies. The main risk is IBD-associated colorectal cancer, which is caused by chronic inflammation, followed by other cancers (including extraintestinal cancers) that develop as a result of the inflammation and subsequent treatment with immunosuppressors/ /biologics. Recent advances in immunosuppressive therapies have significantly improved prognosis as well as quality of life of IBD patients. However, longer survival means prolonged exposure to chronic inflammation as well as to immunosupression (biologics), which translates into a higher risk of cancer development. Therefore, in addition to anti-inflammatory therapies, current strategies for the management of IBD patients also include cancer prevention and surgery, systemic therapy, radiotherapy, and hormonal therapy. The current paper describes the major risk factors of malignancy in IBD patients, and provides an overview of the most commonly occurring IBD-associated gastrointestinal cancers and their management.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database

  • CEP classification

  • OECD FORD branch

    30219 - Gastroenterology and hepatology

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Gastroenterologie a hepatologie

  • ISSN

    1804-7874

  • e-ISSN

  • Volume of the periodical

    71

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    6

  • Pages from-to

    388-393

  • UT code for WoS article

  • EID of the result in the Scopus database

    2-s2.0-85035787004