Levodopa-carbidopa intestinal gel in advanced Parkinson's: Final results of the GLORIA registry
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10366124" target="_blank" >RIV/00216208:11110/17:10366124 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/17:10366124
Result on the web
<a href="http://dx.doi.org/10.1016/j.parkreldis.2017.09.018" target="_blank" >http://dx.doi.org/10.1016/j.parkreldis.2017.09.018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.parkreldis.2017.09.018" target="_blank" >10.1016/j.parkreldis.2017.09.018</a>
Alternative languages
Result language
angličtina
Original language name
Levodopa-carbidopa intestinal gel in advanced Parkinson's: Final results of the GLORIA registry
Original language description
Introduction: This registry evaluated the 24-month safety and efficacy of levodopa-carbidopa intestinal gel (LCIG) treatment in advanced Parkinson's disease (PD) patients under routine clinical care. Methods: Motor fluctuations, dyskinesia, non-motor symptoms, quality of life, and safety were evaluated. Observations were fully prospective for treatment-naive patients (60% of patients) and partially retrospective for patients with <=12 months of pre-treatment with LCIG (40% of patients). Hours of "On" and "Off" time were assessed with a modified version of the Unified Parkinson's Disease Rating Scale part IV items 32 and 39. Results: Overall, 375 patients were enrolled by 75 movement disorder centers in 18 countries and 258 patients completed the registry. At 24 months LCIG treatment led to significant reductions from baseline in "Off" time (hours/day) (mean +- SD = -4.1 +- 3.5, P < 0.001), "On" time with dyskinesia (hours/day) (-1.1 +- 4.8, P = 0.006), Non-Motor Symptom Scale total (-16.7 +- 43.2, P < 0.001) and individual domains scores, and Parkinson's Disease Questionnaire-8 item total score (-7.1 +- 21.0, P < 0.001). Adverse events deemed to have a possible/probable causal relationship to treatment drug/device were reported in 194 (54%) patients; the most frequently reported were decreased weight (6.7%), device related infections (5.9%), device dislocations (4.8%), device issues (4.8%), and polyneuropathy (4.5%). Conclusions: LCIG treatment led to sustained improvements in motor fluctuations, non-motor symptoms particularly sleep/fatigue, mood/cognition and gastrointestinal domains, as well as quality of life in advanced PD patients over 24 months. Safety events were consistent with the established safety profile of LCIG.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Parkinsonism and Related Disorders
ISSN
1353-8020
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
December
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
13-20
UT code for WoS article
000419811700003
EID of the result in the Scopus database
2-s2.0-85031330718