Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10366228" target="_blank" >RIV/00216208:11110/17:10366228 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/17:10366228
Result on the web
<a href="http://dx.doi.org/10.1038/leu.2017.121" target="_blank" >http://dx.doi.org/10.1038/leu.2017.121</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/leu.2017.121" target="_blank" >10.1038/leu.2017.121</a>
Alternative languages
Result language
angličtina
Original language name
Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004
Original language description
We conducted a cytogenetic analysis of 642 children with de novo acute myeloid leukemia (AML) treated on the AML-Berlin-Frankfurt-Munster (BFM) 04 protocol to determine the prognostic value of specific chromosomal aberrations including monosomal (MK+), complex (CK+) and hypodiploid (HK+) karyotypes, individually and in combination. Multivariate regression analysis identified in particular MK+ (n = 22) as a new independent risk factor for poor event-free survival (EFS 23 +/- 9% vs 53 +/- 2% for all other patients, P = 0.0003), even after exclusion of four patients with monosomy 7 (EFS 28 +/- 11%, P = 0.0081). CK+ patients without MK had a better prognosis (n = 47, EFS 47 +/- 8%, P = 0.46) than those with MK+ (n = 12, EFS 25 +/- 13%, P = 0.024). HK+ (n = 37, EFS 44 +/- 8% for total cohort, P = 0.3) influenced outcome only when t(8; 21) patients were excluded (remaining n = 16, EFS 9 +/- 8%, P < 0.0001). An extremely poor outcome was observed for MK+/HK+ patients (n = 10, EFS 10 +/- 10%, P < 0.0001). Finally, isolated trisomy 8 was also associated with low EFS (n = 16, EFS 25 +/- 11%, P = 0.0091). In conclusion, monosomal karyotype is a strong and independent predictor for high-risk pediatric AML. In addition, isolated trisomy 8 and hypodiploidy without t(8; 21) coincide with dismal outcome. These results have important implications for risk stratification and should be further validated in independent pediatric cohorts.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia
ISSN
0887-6924
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
2807-2814
UT code for WoS article
000417177100032
EID of the result in the Scopus database
2-s2.0-85038233250