Polypharmacy and Unplanned Hospitalizations in Patients with Rheumatoid Arthritis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10366229" target="_blank" >RIV/00216208:11110/17:10366229 - isvavai.cz</a>
Alternative codes found
RIV/00023728:_____/17:N0000076
Result on the web
<a href="http://dx.doi.org/10.3899/jrheum.160818" target="_blank" >http://dx.doi.org/10.3899/jrheum.160818</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3899/jrheum.160818" target="_blank" >10.3899/jrheum.160818</a>
Alternative languages
Result language
angličtina
Original language name
Polypharmacy and Unplanned Hospitalizations in Patients with Rheumatoid Arthritis
Original language description
Objective. Polypharmacy (PP), the prescribing of multiple drugs for an individual, is rising in prevalence. PP associates with an increased risk of adverse drug reactions (ADR) and hospital admissions. We investigated the relationship between PP, characteristics of rheumatoid arthritis (RA), and the risk of unplanned hospital admissions. Methods. Patients from a hospital RA cohort were retrospectively analyzed. Information was collected from electronic medical records. Cox proportional hazards were used to compare hospitalization risk according to levels of PP. Admissions were adjudicated to determine whether an ADR was implicated. Results. The study included 1101 patients; the mean number of all medications was 5. PP correlated with increasing age, disease duration, disease activity, and disability. At least 1 unplanned admission occurred for 16% of patients. Patients taking >= 10 medications had an adjusted HR for hospitalization of 3.1 (95% CI 2.1-4.5), compared to those taking 0-5 medications. Corticosteroid use associated with a doubling in adjusted risk of admission of 1.7 (95% CI 1.2-2.4). The most common reason for hospitalization was infection (28%). While in half of all admissions an ADR was a possible contributing factor, only 2% of admissions were found to directly result from an ADR. Conclusion. PP is common in RA and is a prognostic marker associated with increased risk of acute hospitalizations. Our data suggest that PP may be an indicator of comorbidity burden rather than a contributing cause of a drug-related toxicity. PP should be monitored to minimize inappropriate combination of prescribed medications. PP may be a useful predictor of clinical outcomes in epidemiologic studies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30226 - Rheumatology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Rheumatology
ISSN
0315-162X
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
12
Country of publishing house
CA - CANADA
Number of pages
8
Pages from-to
1786-1793
UT code for WoS article
000416883500005
EID of the result in the Scopus database
2-s2.0-85037131403