Atherosclerosis and Cardiovascular Risk in Systemic Sclerosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10366814" target="_blank" >RIV/00216208:11110/17:10366814 - isvavai.cz</a>
Alternative codes found
RIV/00023728:_____/17:N0000017
Result on the web
<a href="https://www.intechopen.com/books/systemic-sclerosis/atherosclerosis-and-cardiovascular-risk-in-systemic-sclerosis" target="_blank" >https://www.intechopen.com/books/systemic-sclerosis/atherosclerosis-and-cardiovascular-risk-in-systemic-sclerosis</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5772/67495" target="_blank" >10.5772/67495</a>

Result language
angličtina
Original language name
Atherosclerosis and Cardiovascular Risk in Systemic Sclerosis
Original language description
Atherosclerosis (ATS) has been considered to be a degenerative disease affecting large and medium-sized arteries, resulting in a passive build-up of cholesterol in the artery wall. In the last decade, immune system was proved to play the key role in the pathogenesis of ATS, suggesting ATS to be more progressive and accelerated in chronic inflammatory conditions. Studies in patients with autoimmune diseases, particularly in the most prevalent ones such as rheumatoid arthritis and systemic lupus erythematosus, confirmed the significantly more serious atherosclerotic disease and increased cardiovascular (CV) risk compared to the general population, suggesting these diseases as an independent risk factor for CV diseases. There are only few studies evaluating ATS and CV risk in systemic sclerosis (SSc). Moreover, these studies present contradictory results. Furthermore, it is complicated to differentiate primary vascular affection related to the pathogenesis of SSc from the secondary vascular infliction due to ATS. Nevertheless, most of the studies to date suggest ATS and its clinical manifestations to be more prevalent in SSc. Future studies evaluating larger cohorts of patients are required to determine the relevance of ATS and CV disease and management of these comorbidities in SSc.
Czech name
—
Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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