Methylprednisolone Modulates Intracranial Pressure in the Brain Cellular Edema Induced by Water Intoxication

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10369383" target="_blank" >RIV/00216208:11110/17:10369383 - isvavai.cz</a>

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/66/66_S511.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/66/66_S511.pdf</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Methylprednisolone Modulates Intracranial Pressure in the Brain Cellular Edema Induced by Water Intoxication

Original language description

Continuous monitoring of the intracranial pressure (ICP) detects impending intracranial hypertension resulting from the impaired intracranial volume homeostasis, when expanding volume generates pressure increase. In this study, cellular brain edema (CE) was induced in rats by water intoxication (WI). Methylprednisolone (MP) was administered intraperitoneally (i.p.) before the start of CE induction, during the induction and after the induction. ICP was monitored for 60 min within 20 h after the completion of the CE induction by fibreoptic pressure transmitter. In rats with induced CE, ICP was increased (Mean +/- SEM: 14.25 +/- 2.12) as well as in rats with MP administration before the start of CE induction (10.55 +/- 1.27). In control rats without CE induction (4.62 +/- 0.24) as well as in rats with MP applied during CE induction (5.52 +/- 1.32) and in rats with MP applied after the end of CE induction (6.23 +/- 0.73) ICP was normal. In the last two groups of rats, though the CE was induced, intracranial volume homeostasis was not impaired, intracranial volume as well as ICP were not increased. It is possible to conclude that methylprednisolone significantly influenced intracranial homeostasis and thus also the ICP values in the model of cellular brain edema.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30105 - Physiology (including cytology)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

—

Volume of the periodical

66

Issue of the periodical within the volume

Supplement 4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

"S511"-"S516"

UT code for WoS article

000422901400008

EID of the result in the Scopus database

—