Electrocardiographic Outcome of Resynchronization Therapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10369384" target="_blank" >RIV/00216208:11110/17:10369384 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/17:10369384 RIV/68407700:21460/17:00319221 RIV/68407700:21730/17:00319221 RIV/00064203:_____/17:10369384

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/66/66_S523.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/66/66_S523.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Electrocardiographic Outcome of Resynchronization Therapy

Original language description

Cardiac resynchronization therapy (CRT) has proven efficacious in reducing or even eliminating cardiac dyssynchrony and thus improving heart failure symptoms. However, quantification of mechanical dyssynchrony is still difficult and identification of CRT candidates is currently based just on the morphology and width of the QRS complex. As standard 12-lead ECG brings only limited information about the pattern of ventricular activation, we aimed to study changes produced by different pacing modes on the body surface potential maps (BSPM). Total of 12 CRT recipients with symptomatic heart failure (NYHA II-IV), sinus rhythm and QRS width &gt;= 120 ms and 12 healthy controls were studied. Mapping system Biosemi (123 unipolar electrodes) was used for BSPM acquisition. Maximum QRS duration, longest and shortest activation times (ATmax and ATmin) and dispersion of QT interval (QTd) were measured and/or calculated during spontaneous rhythm, single-site right- and left-ventricular pacing and biventricular pacing with ECHO-optimized AV delay. Moreover we studied the impact of CRT on the locations of the early and late activated regions of the heart. The average values during the spontaneous rhythm in the group of patients with dyssynchrony (QRS 140.5 +/- 10.6 ms, ATmax 128.1 +/- 10.1 ms, ATmin 31.8 +/- 6.7 ms and QTd 104.3 +/- 24.7 ms) significantly differed from those measured in the control group (QRS 93.0 +/- 10.0 ms, ATmax 79.1 +/- 3.2 ms, ATmin 24.4 +/- 1.6 ms and QTd 43.6 +/- 10.7 ms). Right ventricular pacing (RVP) improved significantly only ATmax [111.2 +/- 10.6 ms (p&lt;0.05)] but no other measured parameters. Left ventricular pacing (LVP) succeeded in improvement of all parameters [QRS 105.1 +/- 8.0 ms (p&lt;0.01), ATmax 103.7 +/- 7.1 ms (p&lt;0.01), ATmin 20.2 +/- 3.7 ms (p&lt;0.01) and QTd 52.0 +/- 9.4 ms (p&lt;0.01)]. Biventricular pacing (BVP) showed also a beneficial effect in all parameters [QRS 121.3 +/- 8.9 ms (p&lt;0.05), ATmax 114.3 +/- 8.2 ms (p&lt;0.05), ATmin 22.0 +/- 4.1 ms (p&lt;0.01) and QTd 49.8 +/- 10.0 ms (p&lt;0.01)]. Our results proved beneficial outcome of LVP and BVP in evaluated parameters (what seems to be important particularly in the case of activation times) and revealed a complete return of activation times to normal distribution when using these CRT modalities.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/NV15-31398A" target="_blank" >NV15-31398A: Features of Electromechanical Dyssynchrony that Predict Effect of Cardiac Resynchronization Therapy</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

66

Issue of the periodical within the volume

Supplement 4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

"S523"-"S528"

UT code for WoS article

000422901400010

EID of the result in the Scopus database

2-s2.0-85041724183