Evaluation of Infliximab Therapy in Children with Crohn's Disease Using Trough Levels Predictors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10370047" target="_blank" >RIV/00216208:11110/17:10370047 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/17:10370047 RIV/00064203:_____/17:10370047 RIV/00064165:_____/17:10370047

Result on the web

<a href="http://dx.doi.org/10.1159/000477962" target="_blank" >http://dx.doi.org/10.1159/000477962</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000477962" target="_blank" >10.1159/000477962</a>

Result language

angličtina

Original language name

Evaluation of Infliximab Therapy in Children with Crohn's Disease Using Trough Levels Predictors

Original language description

Background: In adults, infliximab (IFX) levels correlate with disease activity, and antibodies to IFX (ATIs) predict treatment failure. We aimed to determine the association of IFX levels and ATIs with disease activity in a paediatric population. We prospectively collected blood, stool, and clinical data from 65 patients (age 10.5-15.1 years) with Crohn&apos;s disease (CD) before IFX administration, and measured IFX trough levels, ATIs, and faecal calprotectin levels (CPT). Samples were collected during maintenance therapy. We used multivariate analysis to identify the predictors of IFX levels. Summary: Lower levels of IFX were associated with ATIs positivity (OR 0.027, 95% CI 0.009-0.077). Higher C-reactive protein (CRP) level, erythrocyte sedimentation rate, and CPT levels were found in patients with lower IFX levels. The optimal combination of sensitivity (0.5) and specificity (0.74) for disease activity was calculated for IFX levels &gt;=1.1 µg/mL using CRP level &lt;5 mg/L as a marker of laboratory remission. In a model that used CPT &lt;=100 µg/g as the definition of remission, the optimal IFX trough level was 3.5 µg/mL. No independent association between remission and ATIs was found in our study population. However, we found an independentz association between IFX levels and serum albumin levels (OR 1.364, 95% CI 1.169-1.593), p &lt; 0.001. Key Messages: The paediatric population was similar to adult populations in terms of the association between IFX and ATIs as well as between IFX and disease activity,

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30219 - Gastroenterology and hepatology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Digestive Diseases

ISSN

0257-2753

e-ISSN

—

Volume of the periodical

36

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

40-48

UT code for WoS article

000415245000006

EID of the result in the Scopus database

2-s2.0-85027690993