Gait and Balance Impairment after Acute Methanol Poisoning

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10366684" target="_blank" >RIV/00216208:11110/18:10366684 - isvavai.cz</a>

Alternative codes found

RIV/00064190:_____/18:N0000055 RIV/00064165:_____/18:10366684

Result on the web

<a href="http://dx.doi.org/10.1111/bcpt.12853" target="_blank" >http://dx.doi.org/10.1111/bcpt.12853</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/bcpt.12853" target="_blank" >10.1111/bcpt.12853</a>

Result language

angličtina

Original language name

Gait and Balance Impairment after Acute Methanol Poisoning

Original language description

Neurological sequelae including gait impairment were reported in survivors after methanol intoxication; however, no systematic study has been published so far. We aimed to analyse gait and balance impairment in a group of Czech methanol poisoning survivors. We examined 43 patients (age 46 +- 13 years) 2-8 months after methanol poisoning and 43 healthy controls. Investigations contained a shortened version of Falls Efficacy Scale (FES), clinical tests of gait and balance including Timed Up and Go test (TUG) and gait analysis using GaitRite(R) system, neurological and neuropsychological examination, brain imaging, EMG and tests of alcohol consumption. Nineteen patients admitted balance and gait impairment according to FES. Mild to moderate parkinsonian signs showed seven patients. Patients were slower (8.8 versus 5.7 s, p &lt; 0.001) and performed more steps (11.1 versus 7.9, p &lt; 0.001) in TUG compared with the controls. Gait analysis revealed shorter step length (76.5 versus 88.7 cm, p &lt; 0.001), increased double support phase (18.8 versus 15.5%, p &lt; 0.001) and wider base of support (11.3 versus 9.6 cm, p = 0.006) in patients. Eleven patients had deficit of executive function and performed higher cadence compared to the patients with normal execution (122.7 versus 115.0 step/min., p = 0.025). Lower limb polyneuropathy was verified in nine patients, without relation with gait or balance parameters. Neuroimaging revealed lesions mainly in the basal ganglia. Methanol poisoning survivors presented slower wide-based gait with shortened steps corresponding with frontal gait disorder. Higher stepping cadence associated with executive deficit supported the evidence of frontal lobe dysfunction related to impairment of basal ganglia and connections in frontal cortico-basal ganglia loops.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Basic &amp; Clinical Pharmacology &amp; Toxicology

ISSN

1742-7835

e-ISSN

—

Volume of the periodical

122

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

176-182

UT code for WoS article

000418657100022

EID of the result in the Scopus database

2-s2.0-85028931067