Long-term donors versus non-donor men: Iron metabolism and the atherosclerotic process
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10375116" target="_blank" >RIV/00216208:11110/18:10375116 - isvavai.cz</a>
Alternative codes found
RIV/00064173:_____/18:N0000028 RIV/00216208:11120/18:43916472
Result on the web
<a href="https://doi.org/10.1016/j.atherosclerosis.2018.03.009" target="_blank" >https://doi.org/10.1016/j.atherosclerosis.2018.03.009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.atherosclerosis.2018.03.009" target="_blank" >10.1016/j.atherosclerosis.2018.03.009</a>
Alternative languages
Result language
angličtina
Original language name
Long-term donors versus non-donor men: Iron metabolism and the atherosclerotic process
Original language description
Background and aims: The increased iron level and the labile iron pool (LIP) in circulating monocytes are connected to a higher frequency of cardiovascular events. Methods: The study investigates the relationship between LIP in circulating monocytes and markers of iron metabolism and atherosclerosis (inflammation, oxidative stress, endothelial dysfunction and arterial elasticity) in long-term blood donors and non-donor volunteers. Results: We found that donors had significantly higher LIP values than the control group (1.89 +- 0.47 μM vs. 1.50 +- 0.41 μM, p = 0.007). Despite the observed tendency for the donor group to have higher blood pressure, cholesterol, glucose and HOMAR-IR (homeostasis model assessment of insulin resistance), the groups did not differ in inflammatory markers, markers of endothelial dysfunction and markers of impaired arterial elasticity. The donor group had significant changes in iron metabolism (higher serum Fe, ceruloplasmin, and TfR/Ft ratio (transferrin receptor/ferritin ratio) and lower hepcidin, ferritin, and CD163), indicating depletion of body iron stores and activation of iron turnover. Conclusions: LIP seems to be a good marker of iron turnover activity in these individuals despite the lack of a decrease in the hemoglobin concentration. We did not find a significant correlation between LIP levels and atherosclerosis progression in the two groups. However, further studies are needed to assess long-term donorship as a protective factor against atherosclerosis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NT13671" target="_blank" >NT13671: Intracellular reactive iron in monocytes and its role in atherogenesis</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Atherosclerosis
ISSN
0021-9150
e-ISSN
—
Volume of the periodical
272
Issue of the periodical within the volume
May
Country of publishing house
IE - IRELAND
Number of pages
7
Pages from-to
14-20
UT code for WoS article
000430383800003
EID of the result in the Scopus database
2-s2.0-85043479919