[F-18] Fluorodeoxyglucose PET/CT and prediction of histopathological response to neoadjuvant chemotherapy for adenocarcinoma of the oesophagus and oesophagogastric junction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10375307" target="_blank" >RIV/00216208:11110/18:10375307 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/18:10375307 RIV/00064203:_____/18:10375307 RIV/00023884:_____/18:00007924 RIV/00064165:_____/18:10375307

Result on the web

<a href="https://doi.org/10.1002/bjs.10712" target="_blank" >https://doi.org/10.1002/bjs.10712</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/bjs.10712" target="_blank" >10.1002/bjs.10712</a>

Result language

angličtina

Original language name

[F-18] Fluorodeoxyglucose PET/CT and prediction of histopathological response to neoadjuvant chemotherapy for adenocarcinoma of the oesophagus and oesophagogastric junction

Original language description

BackgroundThe aim of this prospective study was to assess whether [F-18]fluorodeoxyglucose PET can be used to predict histopathological response early in the course of neoadjuvant chemotherapy in patients with adenocarcinoma of the oesophagus and oesophagogastric junction. MethodsFollowing the PET response criteria in solid tumours (PERCIST 1.0) as a standardized method for semiquantitative assessment of metabolic response, FDG-PET/CT was performed before (PET1) and after (PET2) initiation of the first cycle of chemotherapy. The relative changes in the peak standardized uptake value (SUL) and total lesion glycolysis (TLG) between PET1 and PET2 were correlated with histopathological response, defined as less than 50 per cent viable tumour cells in the resection specimen. A receiver operating characteristic (ROC) curve analysis was used to identify the optimal cut-off value with the highest accuracy of histopathological response prediction. ResultsPET2 was performed a median of 16 (range 12-22) days after the start of chemotherapy. Some 27 of 90 patients who underwent surgery had a histopathological response. There was no association between the median SUL or median TLG and the histopathological response. A post hoc analysis in 47 patients with PET2 performed 16days or less after the start of chemotherapy showed that TLG, but not SUL, was associated with the histopathological response (P=0009). The optimal cut-off value of TLG was 66 per cent or more. ConclusionFDG-PET/CT after the first cycle of chemotherapy does not predict histopathological response in patients with adenocarcinoma of the oesophagus and oesophagogastric junction. Of no use

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30212 - Surgery

Project

<a href="/en/project/NT12331" target="_blank" >NT12331: Early assessment of effectivness of neoadjuvant chemotherapy for carcinoma of the esophagus and esophago-gastric junction using FDG-PET/CT.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

British Journal of Surgery

ISSN

0007-1323

e-ISSN

—

Volume of the periodical

105

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

419-428

UT code for WoS article

000426495200014

EID of the result in the Scopus database

2-s2.0-85041647706