HPV infection and P16 expression in oral and oropharyngeal cancer in Kazakhstan
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10375403" target="_blank" >RIV/00216208:11110/18:10375403 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/18:10375403
Result on the web
<a href="https://doi.org/10.1186/s13027-018-0175-8" target="_blank" >https://doi.org/10.1186/s13027-018-0175-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13027-018-0175-8" target="_blank" >10.1186/s13027-018-0175-8</a>
Alternative languages
Result language
angličtina
Original language name
HPV infection and P16 expression in oral and oropharyngeal cancer in Kazakhstan
Original language description
Background: Human papillomavirus (HPV) is an important etiologic factor in different cancers of anogenital region and also in a fraction of head and neck cancers (HNC) particularly oropharyngeal tumors. The HPV16 genotype associated with the majority of HPV-related head and neck carcinomas. Th incidence of oropharyngeal cancer is increasing in many countries, and the rate of HPV positive tumors is about 70% in Europe and North America. Little known about the prevalence of HPV in HNC in Central Asia. Methods: It's a prospective analysis of patients with verified oral or oropharyngeal cancer. Sociodemographic and clinical data obtained on admission to treatment. The diagnosis of HPV positivity assessed by both the P16 expression on immunohistochemistry(IHC) and polymerase chain reaction (PCR) with HPV DNA detection and HR HPV type determination. Results: Seventy six patients with oral and oropharyngeal cancer tested for HPV. Forteen cases were positive for HPV by PCR and 15 cases by P16 IHC. Of the 35 oropharyngeal tumors, nine were HPV DNA and p16 IHC positive, giving the rate of 25.7%. Of the 41 oral tumors, five were HPV DNA and six p16 IHC positive, giving the rate of 12.2%. Conclusion: It is the first study mapping prevalence of HPV positivity in oral and oropharyngeal cancer in the Central Asian region. The rate of HPV positivity was higher in oropharyngeal than in oral cancer, the nonsmokers were significantly more frequent in the HPV positive group and HPV 16 was the most frequent type. However, the HPV positivity rates are lower than referred in the western world.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30206 - Otorhinolaryngology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Infectious Agents and Cancer
ISSN
1750-9378
e-ISSN
—
Volume of the periodical
13
Issue of the periodical within the volume
January
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
—
UT code for WoS article
000419979600001
EID of the result in the Scopus database
2-s2.0-85040446382