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The colorful spectrum of Tourette syndrome and its medical, surgical and behavioral therapies

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376315" target="_blank" >RIV/00216208:11110/18:10376315 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064165:_____/18:10376315

  • Result on the web

    <a href="https://doi.org/10.1016/j.parkreldis.2017.08.004" target="_blank" >https://doi.org/10.1016/j.parkreldis.2017.08.004</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.parkreldis.2017.08.004" target="_blank" >10.1016/j.parkreldis.2017.08.004</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The colorful spectrum of Tourette syndrome and its medical, surgical and behavioral therapies

  • Original language description

    Tourette syndrome (TS) is a common neuropsychiatric disorder, more common in males than females, with onset before age 18. TS is characterized by multiple motor tics and one or more vocal/phonic tics, persisting for more than a year. Tics are unvoluntary, abrupt, rapid, repetitive, but non-rhythmic movements or sounds (vocalizations). They are preceded by an inner urge. Tics can be temporarily suppressed, but this leads to a powerful re-emergence. The performance of tics results in immediate but transient relief. Motor and vocal tics are classified as simple or complex. Tics emerge many times during the day and display spontaneous fluctuations in frequency, type, severity and complexity. Tics improve during concentration, worsen during relaxation or when under stress and occasionally are persistent in sleep. Psychiatric comorbidities such as attention deficit hyperactivity disorder (ADHD), obsessive compulsive disorder (OCD) and others frequently are present. Patients, families and teachers benefit from receiving instruction regarding the character of TS and its specific symptoms and from receiving counseling. Pharmacological treatment is not always necessary. Atypical antipsychotics (e.g. risperidone, ziprasidone, olanzapine, aripiprazole) are often the first-line treatment; typical antipsychotics (e.g. haloperidol, pimozide, fluphenazine), benzodiazepines (clonazepam) and tetrabenazine are employed less frequently. Alpha adrenergic agonists (clonidine, guanfacine), the selective noradrenaline re-uptake inhibitor, atomoxetine, and the amphetamine-like stimulant, methylphenidate, are useful in patients with tics and ADHD; selective serotonin re-uptake inhibitors can be useful in individuals with tics and OCD. Botulinum toxin can be effective in focal tics. In severe, treatment-resistant TS, deep brain stimulation may be beneficial.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30103 - Neurosciences (including psychophysiology)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Parkinsonism and Related Disorders

  • ISSN

    1353-8020

  • e-ISSN

  • Volume of the periodical

    46

  • Issue of the periodical within the volume

    Supplement 1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    5

  • Pages from-to

    "S75"-"S79"

  • UT code for WoS article

    000419811900017

  • EID of the result in the Scopus database

    2-s2.0-85028349359