Landiolol for managing post-operative atrial fibrillation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376344" target="_blank" >RIV/00216208:11110/18:10376344 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/18:10376344
Result on the web
<a href="https://doi.org/10.1093/eurheartj/sux036" target="_blank" >https://doi.org/10.1093/eurheartj/sux036</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/eurheartj/sux036" target="_blank" >10.1093/eurheartj/sux036</a>
Alternative languages
Result language
angličtina
Original language name
Landiolol for managing post-operative atrial fibrillation
Original language description
Beta-blockers are a potential option to manage peri-operative atrial fibrillation. Landiolol is a new ultra-short beta-blocker with a half-life of only 4 minutes and very high beta-1 selectivity which has been used for treatment and prevention of atrial fibrillation in pulmonary surgery and gastro-intestinal surgery. Due to its limited negative inotropic effect and high beta-1 selectivity landiolol allows for control of heart rate with minimal impact on blood pressure. Landiolol is well tolerated by the respiratory system. Additional benefits are related to the regulation of the inflammatory response and blunting of the adrenergic pathway. There is a limited number of trials with total of 61 patients undergoing lung resection or oesophagectomy who developed post-operative atrial fibrillation and were treated with landiolol. The experience with landiolol for prevention is more documented than landiolol application for treatment of post-operative atrial fibrillation. There are 9 comparative studies with a total of 450 patients administered landiolol for prevention of post-operative atrial fibrillation. The use of low dosage (5-10mcg/kg/min) is usually sufficient to rapidly control heart rate which is associated with earlier and higher rate of conversion to sinus rhythm as compared to the controls. The excellent tolerance of landiolol at lower dosage (3-5mcg/kg/min) allows to initiate prophylactic use during surgery and postoperatively. Landiolol prophylaxis is associated with reduced incidence of post-operative atrial fibrillation without triggering adverse events related to a beta-blockade.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30223 - Anaesthesiology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Heart Journal: Supplements
ISSN
1520-765X
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
Supplement A
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
"A10"-"A14"
UT code for WoS article
000422970300003
EID of the result in the Scopus database
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