Phenotypes of organ involvement in sarcoidosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376434" target="_blank" >RIV/00216208:11110/18:10376434 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/18:73584974 RIV/00098892:_____/18:N0000004 RIV/00064190:_____/18:N0000050 RIV/00064165:_____/18:10376434

Result on the web

<a href="https://doi.org/10.1183/13993003.00991-2017" target="_blank" >https://doi.org/10.1183/13993003.00991-2017</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1183/13993003.00991-2017" target="_blank" >10.1183/13993003.00991-2017</a>

Result language

angličtina

Original language name

Phenotypes of organ involvement in sarcoidosis

Original language description

Sarcoidosis is a highly variable, systemic granulomatous disease of hitherto unknown aetiology. The GenPhenReSa (Genotype-Phenotype Relationship in Sarcoidosis) project represents a European multicentre study to investigate the influence of genotype on disease phenotypes in sarcoidosis. The baseline phenotype module of GenPhenReSa comprised 2163 Caucasian patients with sarcoidosis who were phenotyped at 31 study centres according to a standardised protocol. From this module, we found that patients with acute onset were mainly female, young and of Scadding type I or II. Female patients showed a significantly higher frequency of eye and skin involvement, and complained more of fatigue. Based on multidimensional correspondence analysis and subsequent cluster analysis, patients could be clearly stratified into five distinct, yet undescribed, subgroups according to predominant organ involvement: 1) abdominal organ involvement, 2) ocular-cardiac-cutaneous-central nervous system disease involvement, 3) musculoskeletal-cutaneous involvement, 4) pulmonary and intrathoracic lymph node involvement, and 5) extrapulmonary involvement. These five new clinical phenotypes will be useful to recruit homogenous cohorts in future biomedical studies.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30203 - Respiratory systems

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Respiratory Journal

ISSN

0903-1936

e-ISSN

—

Volume of the periodical

51

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

—

UT code for WoS article

000424355100003

EID of the result in the Scopus database

2-s2.0-85050411045