The Effect of Adrenalectomy on Exercise Response of the Renin-Angiotensin-Aldosterone System and Exercise Tolerance in Primary Aldosteronism

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376470" target="_blank" >RIV/00216208:11110/18:10376470 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/18:10376470

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/67/67_233.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/67/67_233.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The Effect of Adrenalectomy on Exercise Response of the Renin-Angiotensin-Aldosterone System and Exercise Tolerance in Primary Aldosteronism

Original language description

Primary aldosteronism (PA) is associated with objectively measured lower physical fitness and blunted response of the renin-angiotensin-aldosterone system to exercise. The purpose of this pilot study was to objectively measure exercise response of the renin-angiotensin-aldosterone system and cardiopulmonary fitness changes after laparoscopic adrenalectomy (ADE) in patients with unilateral PA. We examined a total of 14 patients with confirmed PA before and after ADE, by means of spiroergometry and hormonal evaluation. As expected, after adrenalectomy basal aldosterone (Aldo) levels before exercise decreased significantly, with a concomitant increase in plasma renin (PR). The increase in Aldo (285.9 +/- 171.3 to 434.1 +/- 278.2 ng/l; p=0.02) and blunted increase in PR (7.1 +/- 0.4 to 8.9 +/- 10.4 pg/ml; NS) post-exercise before ADE became significant after ADE Aldo post-ADE (46.8 +/- 18.8 to 106.5 +/- 68.1 ng/l; p&lt;0.0001) and PR post-ADE (20.1 +/- 14.5 to 33.9 +/- 30.7 pg/ml; p=0.014). After adrenalectomy, the patients had a non-significant increase in peak workload and VO2peak. We found normalization of the renin-angiotensin-aldosterone system response to exercise with little changes in cardiopulmonary fitness six months after ADE.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

67

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

233-238

UT code for WoS article

000431452400009

EID of the result in the Scopus database

2-s2.0-85046704645