Very long-term outcome of schizophrenia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376802" target="_blank" >RIV/00216208:11110/18:10376802 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/18:10376802

Result on the web

<a href="https://doi.org/10.1111/ijcp.13094" target="_blank" >https://doi.org/10.1111/ijcp.13094</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ijcp.13094" target="_blank" >10.1111/ijcp.13094</a>

Result language

angličtina

Original language name

Very long-term outcome of schizophrenia

Original language description

PurposeThe principal aim is to review recent data concerning the very long-term outcome of schizophrenia and schizophrenia spectrum disorders. We examine factors that influence outcome, including therapeutic interventions. MethodPubMed and Scopus databases were searched for papers published between 2008 and 2017 reporting on prospective studies of schizophrenia or schizophrenia spectrum with a follow-up period 5years with adequate outcome information. Additional publications were found in reference lists and authors&apos; reference libraries. ResultsThe average proportion of patients with symptomatic remission at follow-up ranged between 16.4% in never-treated patients to 37.5% in patients who were systematically treated with antipsychotics. Good outcomes at follow-up were observed in schizophrenia and schizophrenia spectrum patients on low doses of antipsychotics and in patients with no pharmacological treatment at that time. Early detection and intensive treatment of the first episode as well as the availability of continued psychosocial treatment and support over subsequent years appeared associated with better outcomes. ConclusionThe long-term outcome of schizophrenia is highly variable, depending on access to mental healthcare, early detection of psychosis and pharmacological treatment. Recent data support the effectiveness of low-dose antipsychotic treatment for long-term maintenance in some patients. A proportion of first-episode schizophrenia patients, perhaps 20%, do not need long-term maintenance antipsychotic treatment. That proportion may be higher in schizophrenia spectrum patients. The reasons why these patients do not need the long-term treatment are not well understood. Methods to predict the membership in this subgroup are not yet good enough for clinical use in individual patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30215 - Psychiatry

Project

<a href="/en/project/NV17-32445A" target="_blank" >NV17-32445A: Causes of assaultive behavior among patients with psychosis</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Clinical Practice

ISSN

1368-5031

e-ISSN

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Volume of the periodical

72

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

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UT code for WoS article

000438027900002

EID of the result in the Scopus database

2-s2.0-85046373277